AQA GCSE Biology Biology Paper 2 (Higher), June 2025: Question 6

12 marks · Standard Demand difficulty · Short Answer

Identify stages and characteristics of cell division in human spermatogenesis and compare sexual and asexual reproduction in strawberry plants.

Practise this question

Question

Question 06 contains two diagrams. Figure 5 depicts human sperm formation starting from cell A dividing into two cells by Cell division 1, forming four cells including B and C, which then undergoes growth into D. D undergoes Cell division 2 into E and F, which undergo Cell division 3 to form G, H, I, and J, eventually differentiating into sperm cells. Sub-questions 06.1 to 06.4 ask to identify which division is mitosis, which cells are identical, the chromosome number in cell J, and how many cells contain a Y chromosome. Figure 6 shows a strawberry plant reproducing sexually via flowers, fruits, and seeds, and asexually via runners producing offspring plants. Sub-questions 06.5 to 06.8 ask for explanations of genetic identicalness and diversity, and two advantages each of asexual and sexual reproduction.
Question text

06 New cells are produced by cell division.

Figure 5 shows sperm formation in a human.

Figure 5

06.1 Which cell division in Figure 5 represents mitosis?

[1 mark]

Tick ( ) one box.

Cell division 1

Cell division 2

Cell division 3

06.2 Which two cells in Figure 5 are genetically identical?

[1 mark]

Tick ( ) one box.

A and C B and I F and J G and H

06.3 How many chromosomes are there in cell J in Figure 5?

[1 mark]

06.4 How many of the cells C, D, E, F, G, H, I and J contain a Y chromosome?

Use Figure 5.

[1 mark]

Strawberry plants can reproduce both sexually and asexually.

Figure 6 shows a strawberry plant reproducing:

• sexually using flowers, fruits and seeds

• asexually using horizontal stems called runners.

Figure 6

06.5 Explain why the offspring produced using runners are genetically identical.

[2 marks]

06.6 Explain why the offspring produced using flowers, fruits and seeds

are not genetically identical.

[2 marks]

06.7 Describe two advantages of asexual reproduction for the survival of

strawberry plants.

[2 marks]

06.8 Describe two advantages of sexual reproduction for the survival of

strawberry plants.

[2 marks]

Mark scheme

Show the mark scheme Mark scheme for Question 6 lists the acceptable answers: 06.1 is 'cell division 1'; 06.2 is 'A and C'; 06.3 is '23' or 'twenty three'; 06.4 is '5 / five' or '6 / six'. 06.5 requires '(only) mitosis' and '(so) all cells receive a copy of every allele / gene'. 06.6 requires gametes produced by meiosis and offspring having unique/different/random combinations of alleles/genes/chromosomes. 06.7 lists advantages of asexual reproduction: faster, many offspring colonise area, adapted to current conditions, single parent, sharing parent resources, less energy needed. 06.8 lists advantages of sexual reproduction: genetic variation, seed dispersal over wider areas, larger number of offspring.

Question 6

AO /

Question Answers Extra information Mark

Spec. Ref.

06.1 cell division 1 1 AO2

4.1.2.2

4.6.1.1

4.6.1.2

AO /

Spec. Ref.

06.2 A and C 1 AO2

4.1.2.2

4.6.1.1

4.6.1.2

AO /

Spec. Ref.

06.3 23 do not accept 23 pairs 1 AO2

or 4.6.1.2

twenty three 4.6.1.8

AO /

Spec. Ref.

06.4 5 / five ignore reference to letters 1 AO2

or 4.6.1.2

6 / six 4.6.1.8

AO /

Spec. Ref.

06.5 (only) mitosis do not accept meiosis / meitosis 1 AO1

/ metosis

(so) all cells receive a copy of allow (so) all cells receive a 1 AO2

every allele / gene copy of every chromosome

or

(so) all cells receive a copy of 4.6.1.1

all the DNA 4.1.2.2

or 4.6.1.3

(so) all cells receive a full set of

chromosomes

AO /

Spec. Ref.

06.6 gametes are produced by 1 AO1

meiosis

(so) offspring have unique / allow (so) gametes fuse creating 1 AO2

different / random combinations unique / different / random

of alleles / genes / chromosomes combinations of alleles / genes / 4.6.1.1

from each parent / gamete chromosomes in offspring 4.6.1.2

AO /

Spec. Ref.

06.7 any two from: 2 AO1

4.6.1.1

• faster than sexual 4.6.1.3

• many offspring produced to

colonise local area

or

many offspring produced to

out-compete other species

• genetically identical offspring

so well adapted to current

conditions / environment

• only one parent needed so no

need for pollinators / bees

• offspring receive water and

sugars / minerals / ions / salts

from parent

• less energy / materials

required as no need to

produce gametes / flowers /

seeds / fruits

AO /

Spec. Ref.

06.8 any two from: 2 AO1

4.6.1.1

• new combinations of alleles allow genetic variation provides 4.6.1.3

gives genetic variation the opportunity for evolution 4.6.2.2

or 4.6.3.1

genetic variation gives allow genetic variation enables

selective advantage species to adapt to new /

changed environments

• seeds dispersed to new /

wider area so less vulnerable

to habitat loss

or

seeds dispersed to new /

wider area so not competing

with (parent / offspring) plants

for space / water / minerals

• larger number of offspring allow larger number of offspring

produced so will increase the produced will improve survival of

population quickly the species

Total Question 6 12

How to answer it

Cell Division, Gametogenesis & Plant Reproduction

WHAT THIS QUESTION TESTS

This question evaluates your understanding of cell division, genetics, and modes of reproduction across human and plant contexts:

  • Distinguishing between mitosis (produces 2 genetically identical diploid cells) and meiosis (produces 4 genetically varied haploid gametes).
  • Haploid chromosome numbers in human gametes (sperm cells) and sex chromosome segregation (X vs Y).
  • Explaining genetic identity in asexual reproduction (runners) vs genetic variation in sexual reproduction (flowers, pollen, and seeds).
  • Evaluating evolutionary and survival advantages of sexual and asexual reproduction in plants.
PARTS 06.1 & 06.2

Identifying Mitosis and Cloned Cells in Gametogenesis

Cell divisions leading to sperm formation (Figure 5)

Diagram Flow Recap (Figure 5):
• Cell division 1: Cell A divides into two cells (including B), and B divides into two cells (including C). This is mitosis multiplying spermatogonia.
• Growth: Cell C grows to form diploid primary spermatocyte D.
• Cell division 2 (Meiosis I): D divides into two intermediate haploid cells, E and F.
• Cell division 3 (Meiosis II): E and F divide again to produce four spermatids: G, H, I, and J.
• Differentiation: Spermatids develop flagella to become mature sperm cells.

✅ Correct Answers

06.1: Cell division 1 [1 mark]

06.2: A and C [1 mark]

💡 Key Knowledge

  • Mitosis produces two genetically identical cells from one parent cell. All cells formed solely by mitosis from cell A (such as B and C) are identical clones.
  • Meiosis involves two consecutive divisions (divisions 2 and 3) resulting in four non-identical haploid cells.

🧠 Exam Technique

Trace the lineage: Cell division 1 keeps duplicating cells without halving chromosome sets. Divisions 2 & 3 represent the two stages of meiosis because one cell (D) yields four gametes (G, H, I, J).

❌ Common Errors

Assuming all cell division in the testes is meiosis. Stem cells / spermatogonia divide by mitosis first to ensure the male never runs out of sperm-producing cells.

PARTS 06.3 & 06.4

Chromosome Numbers & Sex Chromosomes

Tracking chromosomes through human meiosis

✅ Correct Answers

06.3: 23 (or twenty-three) [1 mark]

06.4: 5 (or 6) [1 mark]

📐 How 06.4 is Calculated

A normal human male body cell has sex chromosomes XY:

  1. Cell C: Diploid spermatogonium = has Y (1)
  2. Cell D: Diploid cell after DNA replication = has Y (1)
  3. Meiosis I (Division 2): Homologous pair XY separates. One daughter cell (e.g. E or F) gets the Y chromosome, the other gets X. That adds 1 cell.
  4. Meiosis II (Division 3): The cell with the replicated Y divides its chromatids into two sperm cells (e.g. G & H or I & J). That adds 2 cells.
  5. Total containing Y: 1 (C) + 1 (D) + 1 (E or F) + 2 (two sperm) = 5 cells.

Note: The mark scheme also generously permits 6 if students considered both intermediate cells or alternative chromatid counting.

❌ Common Trap in 06.3

Writing "23 pairs" instead of "23". Sperm and egg cells are haploid—they have 23 single chromosomes, not pairs! The mark scheme explicitly states: "do not accept 23 pairs".

🧠 Exam Tip for 06.4

Remember that gametes are haploid: 50% of sperm receive an X chromosome, and 50% receive a Y chromosome.

PARTS 06.5 & 06.6

Explaining Variation: Runners vs Seeds

Linking division types to genetic outcomes (2 marks each)

✅ Model Answers

06.5 (Runners):

  • Offspring are formed by (only) mitosis [1 mark].
  • So all cells receive an identical copy of every gene / allele (or a full copy of all DNA) [1 mark].

06.6 (Flowers & Seeds):

  • Gametes (pollen and ovules) are produced by meiosis [1 mark].
  • Fertilisation leads to random combinations of alleles / genes from two gametes/parents [1 mark].

🧠 Two-Mark Structure

For questions asking why offspring are or are not identical, always structure your answer in two steps:

  1. Name the type of cell division involved (mitosis for runners; meiosis for flowers/seeds).
  2. State the genetic consequence (exact copies of alleles passed on vs mix/random assortment of alleles).

❌ Examiner Warning: Spelling Matters!

Do not write blended words like "meitosis" or "metosis". Examiners cannot give benefit of the doubt if it is unclear whether you mean mitosis or meiosis.

💡 Key Knowledge

Sexual reproduction always introduces variation because:

  • Meiosis produces genetically non-identical gametes.
  • Random fertilisation combines different alleles from two parents.
PARTS 06.7 & 06.8

Survival Advantages: Asexual vs Sexual

Ecological and evolutionary benefits for strawberry plants

✅ 06.7: Advantages of Asexual Reproduction (Runners)

Any two from:

  • Faster process than sexual reproduction [1 mark].
  • Many offspring produced rapidly to colonise the local area / outcompete weeds [1 mark].
  • Offspring are well-adapted to the existing stable environment [1 mark].
  • Only one parent needed (no need for pollinators like bees) [1 mark].
  • Offspring receive water, sugars, and minerals directly from the parent plant via the runner [1 mark].
  • Saves energy/materials (no need to construct flowers, nectar, or large fruit) [1 mark].

✅ 06.8: Advantages of Sexual Reproduction (Seeds)

Any two from:

  • Genetic variation: Produces new combinations of alleles, allowing the population to adapt to environmental change or disease (selective advantage / evolution) [1 mark].
  • Seed dispersal: Seeds are carried away (by animals eating fruit), reducing competition with the parent for light, space, and water [1 mark].
  • Less vulnerable to local habitat loss because seeds colonise new areas [1 mark].
  • Can produce a large number of offspring ensuring survival of the species [1 mark].

❌ Common Misconceptions

  • Vague answers: Saying just "it is easier" or "it is good for them" earns 0 marks. Use biological terms: energy-efficient, independent of pollinators, or genetic diversity.
  • Confusing advantages: Claiming asexual reproduction creates variation—it produces clones!

🧠 Top Tip: Survival Context

Notice the question says "for the survival of strawberry plants". Relate benefits to real plant ecology: connecting runner roots share nutrients, while fruits attract birds to disperse seeds far away.

Topics

Biology · B1: Cell Biology · B6: Inheritance, Variation and Evolution

Question and mark scheme from the AQA GCSE Biology examination, Biology Paper 2 (Higher), June 2025. QuestionVault is an independent revision resource; questions remain the copyright of the awarding body.