AQA GCSE Combined Science: Trilogy Biology Paper 2 (Higher), 2020: Question 1

9 marks · Standard Demand difficulty · Short Answer

Identify a DNA molecule, describe DNA structure and gene function, define genome, recognise an application of genome knowledge, and explain variation and natural selection using snail examples.

Practise this question

Question

A GCSE Biology question page labelled question 01 states that the question is about DNA and genes. It includes seven short sub-questions: choosing which of three diagrams represents DNA, describing DNA structure, completing sentences about a gene coding for a sequence of amino acids to make a protein, defining genome, selecting an advance made using knowledge of the human genome, naming the term variation from a figure showing six labelled snails M to R with different shell appearances, and suggesting why a DNA change causing snail P to differ might lead to more similar snails in future generations. The page includes simple line drawings: three candidate molecule diagrams with the middle one as a double helix, and a figure of six snails with visibly different shell sizes, patterns and shading.
Question text

01 This question is about DNA and genes.

01.1 Which diagram represents a DNA molecule?

[1 mark]

Tick ( ) one box.

01.2 Describe the structure of a DNA molecule.

[1 mark]

01.3 A gene is a small section of DNA on a chromosome.

Complete the sentences.

[2 marks]

A gene codes for a particular sequence of .

This sequence makes a specific 3 .

01.4 What is meant by the term genome?

[1 mark]

01.5 The complete human genome is now known.

Which important scientific advance was made using knowledge of the

human genome?

*02* [1 mark]

Tick ( ) one box.

Discovering antibiotic resistant bacteria

Finding more foods to eat from tropical forests

Tracing how aboriginal people spread across Australia

Working out when the last ice age ended4

A student found six different snails of one species in his garden.

Figure 1 shows the snails.

Figure 1

01.6 All the snails are different.

What scientific term describes differences in characteristics between individuals of

a species?

[1 mark]

01.7 A change in DNA has caused snail P to be very different from the other five snails.

Suggest why there might be an increasing number of snails similar to snail P in each

future generation.

[2 marks]

Mark scheme

Show the mark scheme The mark scheme is a table with columns for question number, answers, extra information, mark, and AO/spec reference. It awards marks for identifying the double helix as DNA; describing DNA as two twisted or coiled strands forming a double helix or long polymer; stating that genes code for a sequence of amino acids making a protein; defining genome as all the genetic material of an organism; selecting tracing how aboriginal people spread across Australia as a use of genome knowledge; naming variation; and explaining natural selection for snail P using ideas such as stronger or larger shell, better camouflage, increased survival, breeding, and passing on genes. The total shown is 9 marks.

AO /

Question Answers Extra information Mark

Spec. Ref.

01.1 1 AO2

4.6.1.3

01.2 any one from: 1 AO1

• 2 strands / chains that are allow cross links between 2 4.6.1.3

twisted / coiled / spiralled strands / chains

• double helix

• (long) polymer

allow reference to nucleotides or

sugars, phosphates and bases

01.3 in this order only AO1

amino acids 1 4.6.1.3

protein allow polypeptide 1

01.4 all the genetic material (of an allow DNA / genes for genetic 1 AO1

organism) material 4.6.1.3

ignore chromosomes

01.5 tracing how aboriginal people 1 AO2

spread across Australia 4.6.1.3

01.6 variation – OMBINED SCIENCE:ignore genetic/environmentalTRILOGY– 1 – AO1

4.6.2.1

01.7 stronger / larger (shell) 1 AO2

4.6.2.2

(so) more likely to (survive and) 1

breed

or

(so) more likely to (survive and)

pass on genes

OR

(better) camouflaged (1)

(so) less likely to be eaten and

will breed more (1)

Total 9

How to answer it

DNA, Genes and Variation

What this question tests
This question checks whether you can identify the DNA double helix, describe DNA structure, complete simple gene and protein statements, define genome, and explain how genetic information can be used in science. It also tests your understanding of variation and natural selection in a familiar example.

Part (a) 01.1 – Which diagram represents a DNA molecule?

1 mark

✅ Correct answer

Tick the middle diagram. It shows the double helix shape of DNA.

💡 Key knowledge

  • DNA is shaped like a twisted ladder.
  • This structure is called a double helix.
  • It consists of two strands coiled around each other.

🧠 Exam technique

For a 1-mark image question, choose the diagram that matches the standard textbook model of DNA. You do not need extra explanation unless asked.

❌ Common errors

  • Picking the wrong shape because it “looks scientific”.
  • Confusing DNA with a cell, chromosome, or molecule diagram that is not the double helix.

Part (b) 01.2 – Describe the structure of a DNA molecule

1 mark

✅ Correct answer

DNA is made of two strands twisted/coiled around each other to form a double helix.

💡 Key knowledge

  • Accept: two strands, twisted, coiled, or spiralled.
  • You could also mention DNA is a long polymer.
  • Examiner note: references to cross-links between the two strands are allowed.

🧠 Exam technique

For 1 mark, one accurate statement is enough. The safest answer is to say “two strands twisted into a double helix”.

❌ Common errors

  • Writing only “a helix” without saying it has two strands.
  • Confusing DNA structure with the idea of genes or chromosomes.
  • Giving very vague answers like “it is shaped like a ladder” without showing twisting.

Part (c) 01.3 – Complete the sentences about genes

2 marks

✅ Correct answers

A gene codes for a particular sequence of amino acids .

This sequence makes a specific protein .

💡 Key knowledge

  • Genes are sections of DNA that contain instructions.
  • The order is important: DNA → amino acids → protein.
  • Accept polypeptide for protein.

🧠 Exam technique

Marks are awarded in the correct order. Even if you know the ideas, the answer must fit each blank properly.

❌ Common errors

  • Writing “protein” in the first blank.
  • Putting the words in the wrong order.
  • Saying “a gene codes for a trait” instead of the required biological sequence.

Part (d) 01.4 – What is meant by the term genome?

1 mark

✅ Correct answer

The genome is all the genetic material of an organism.

💡 Key knowledge

  • You may also see: all the DNA or all the genes.
  • It refers to the complete set of genetic information.

🧠 Exam technique

Use the exact idea of whole genetic material. This is a definition question, so keep it precise.

❌ Common errors

  • Saying chromosomes alone is enough.
  • Giving a description of one gene instead of the whole organism’s genetic material.

Part (e) 01.5 – An important scientific advance using the human genome

1 mark

✅ Correct answer

Tracing how Aboriginal people spread across Australia

💡 Key knowledge

  • Genome information can be used to study ancestry and population movement.
  • This question expects the example from the mark scheme, not a random use of genome data.

🧠 Exam technique

When a question asks for one correct example, choose the option that directly uses DNA/genome comparisons for human history.

❌ Common errors

  • Choosing an answer that sounds scientific but is unrelated to the genome.
  • Thinking the human genome is mainly used for food, weather, or climate questions.

Part (f) 01.6 – What scientific term describes differences in characteristics between individuals of a species?

1 mark

✅ Correct answer

Variation

💡 Key knowledge

  • Variation means individuals in a species are not all exactly the same.
  • Differences can be inherited or caused by the environment.

🧠 Exam technique

This is a straight recall term. Give the exact scientific word.

❌ Common errors

  • Writing a full explanation instead of the key term.
  • Confusing variation with evolution or adaptation.

Part (g) 01.7 – Why might there be more snails like snail P in future generations?

2 marks

✅ Correct answer

Snail P may have a stronger/larger shell, so it is more likely to survive and breed.

Alternatively, it may be better camouflaged, so it is less likely to be eaten and will breed more.

💡 Key knowledge

  • Useful traits help an organism survive.
  • Organisms that survive are more likely to reproduce.
  • They pass the helpful genes to their offspring.

🧠 Exam technique

To get both marks, link the feature of snail P to survival and then to breeding/passing on genes. This is the full explanation the examiner wants.

❌ Common errors

  • Only describing snail P as different, without explaining why it becomes more common.
  • Missing the key idea of survive → reproduce → pass on genes.
  • Using vague language like “it is better” without saying why that helps.

📐 Quick answer structure for 2-mark biology explanations

  1. State the feature: stronger/larger shell or better camouflage.
  2. Explain the advantage: less likely to be eaten / more likely to survive.
  3. Finish with inheritance: more likely to breed and pass on the genes.

Overall examiner insight

💡 What the examiner rewards

  • Accurate key terms: double helix, amino acids, protein, genome, variation.
  • Clear links in explanations, especially in the snail question.
  • Using the exact order required in fill-in-the-blank questions.

🧠 Best revision takeaway

Learn the simple chain:

DNA → gene → amino acid sequence → protein → characteristic

And for evolution questions:

variation → survival advantage → breeding → genes passed on

Topics

Biology · B6: Inheritance, Variation and Evolution

Question and mark scheme from the AQA GCSE Combined Science: Trilogy examination, Biology Paper 2 (Higher), 2020. QuestionVault is an independent revision resource; questions remain the copyright of the awarding body.