AQA GCSE Combined Science: Trilogy Biology Paper 1 (Higher), 2022: Question 6
9 marks · Standard Demand difficulty · Extended Answer
Answer questions about the heart, including why it is an organ, the effects of a leaking heart valve, and the advantages and disadvantages of using a biological valve instead of a mechanical valve.
Practise this questionQuestion
Question text
06 This question is about the heart.
06.1 Why is the heart described as an organ?
[1 mark]
06.2 Valves in the heart keep the blood flowing through the heart in one direction.
Figure 11 shows the heart with one of the valves labelled.
Figure 11
Explain the effects on a person if the valve labelled in Figure 11 developed a leak.
[4 marks]
06.3 Faulty heart valves can be replaced using biological or mechanical valves.
The faulty valve is replaced during an operation.
*26* Biological valves:
• are from animals or human donors
• allow blood to flow through them normally
• wear out and stiffen over time, so may need to be replaced.
Mechanical valves:
• are made from synthetic materials
• may cause blood clots on the surface of the valve
• require anti-clotting drugs to be taken for the rest of the patient’s life
• can last for a very long time in ideal conditions.
A young woman enjoys extreme sports and would like to start a family.
The woman needs a heart valve replacing.
Describe the advantages and disadvantages for this young woman of having a
biological heart valve instead of a mechanical heart valve.
[4 marks]
Mark scheme
Show the mark scheme
Question 6
AO /
Question Answers Extra information Mark
Spec. Ref.
06.1 it is made up of (different) 1 AO1
tissues (that perform specific 4.2.1
functions)
AO /
Spec. Ref.
06.2 some blood would flow back into allow not all the blood would 1 AO2
the ventricle / heart leave the ventricle / heart 4.2.1
allow blood clot (may form in the 4.2.2.2
heart) 4.2.2.4
do not accept blood would flow 4.4.2.1
back into the right ventricle
(so) less oxygenated blood ignore references to glucose 1
would be pumped to the body
cells require oxygen for allow more anaerobic respiration 1
respiration
or
less aerobic respiration
(so) person would become out (so) lactic acid will build up 1
of breath
or
(so) less energy transferred allow the idea of lacking energy
do not accept less energy
produced / made / created
or
(so) person would be tired– OMBINED SCIENCE: TRILOGY – –
AO /
Spec. Ref.
06.3 max three marks if only AO3
advantages or disadvantages of
4.2.2.2
biological valve given
any four from: 4 4.2.2.3 25
4.2.2.4
(advantages of biological valve):
• reduced risk of blood clots
which could cause heart
attack or stroke
• reduced risk of blood clots
during pregnancy / birth
• reduced risk of bleeding
during pregnancy / birth
• do not need to take anti ignore do not need to take blood
(blood) clotting drugs thinners
allow do not need to take drugs
for life
• no risk to foetus / baby from
drugs
• reduced risk of serious bleeds
if in an accident
• do not need to carry (anti- allow problems related to losing
blood clotting) drugs when / obtaining drugs when travelling
travelling
• lower risk of rejection / do not credit reference to
immune reaction rejection twice
allow no risk of side effects from
drugs
(disadvantages of biological
valve):
• may be rejected do not credit reference to
rejection twice
• may have to go through ignore risks from surgery
surgery more than once unqualified
• may have to take
immunosuppressant drugs allow an animal might be killed
• have to wait for (suitable)
donor
Total Question 6 9
How to answer it
Heart valves: organ, effects of a leak, and valve replacement
Question focus
✅ Correct answers
- 06.1: The heart is an organ because it is made of different tissues that work together for a specific function.
- 06.2: A leak in the valve lets some blood flow backwards, so less oxygenated blood reaches the body.
- 06.3: For this woman, biological valves avoid lifelong anti-clotting drugs, which is helpful if she wants children and does extreme sports.
🧠 Exam technique
- Use the command word: “why”, “explain”, and “describe” need different depth.
- For 4-mark explanations, chain cause → effect → consequence.
- Compare biological and mechanical valves using the given context: pregnancy, sports, and medication.
❌ Common errors
- Saying “an organ is a body part” without mentioning tissues.
- Describing blood flowing into the wrong chamber instead of backflow from the valve leak.
- For 06.3, giving only advantages or only disadvantages: that limits the mark.
Part 06.1 — Why is the heart described as an organ? [1 mark]
✅ Correct answer
The heart is made up of different tissues that perform specific functions.
💡 Key knowledge
- An organ is a group of different tissues.
- The tissues work together to carry out a function.
- For the heart, the function is pumping blood around the body.
🧠 Exam technique
For a 1-mark definition question, give the exact biology idea rather than a vague description. “Different tissues working together” is the safest wording.
Part 06.2 — Effects of a leaking valve [4 marks]
The valve should stop blood going backwards through the heart.
✅ Mark-point answer
- Some blood would flow back into the ventricle / heart.
- So less oxygenated blood would be pumped to the body.
- Cells would have less oxygen for aerobic respiration.
- The person would become tired / out of breath / have less energy.
💡 Key knowledge
- Valves keep blood flowing in one direction.
- If a valve leaks, it does not fully close.
- That means not all blood leaves the ventricle or heart chamber.
- Reduced oxygen supply means less aerobic respiration in cells.
🧠 How marks are awarded
Examiners credited each linked stage:
- backflow happens
- less oxygenated blood is pumped out
- cells need oxygen for respiration
- result: tiredness / breathlessness / less energy
❌ Common errors
- “Blood would flow into the right ventricle” — this was not the accepted idea.
- Talking only about glucose instead of oxygen.
- Saying “less energy produced” is too vague unless linked to respiration.
- Missing the final effect on the person, such as being tired or out of breath.
📐 Step-by-step chain for full marks
- The valve leaks.
- Some blood flows backwards instead of all moving forwards.
- Less oxygenated blood is pumped to the body.
- Body cells get less oxygen for aerobic respiration.
- The person becomes tired or short of breath.
Part 06.3 — Biological or mechanical valve for a young woman? [4 marks]
She enjoys extreme sports and wants to start a family.
✅ Strong answer points
Biological valves would be a good choice because:
- They allow blood to flow normally and have a reduced risk of blood clots.
- This is safer for pregnancy and birth because there is less risk of clotting problems or bleeding problems from anti-clotting drugs.
- She would not need to take anti-clotting drugs for life, which is better for someone doing extreme sports because serious bleeding after an accident is less likely.
- There is also less risk of problems for a foetus / baby from drugs.
💡 Key knowledge
Biological valves:
- Come from animals or human donors.
- Work normally with blood flow.
- Wear out over time.
- Usually do not need lifelong anti-clotting drugs.
Mechanical valves:
- Are synthetic.
- Can last a long time.
- May cause blood clots.
- Need anti-clotting drugs for life.
🧠 What top answers did
- Gave both advantages and disadvantages of biological valves.
- Linked the decision to the woman’s lifestyle and future pregnancy.
- Compared against the mechanical valve idea, especially lifelong drugs and clotting risk.
❌ Common errors
- Only saying “biological valves are better” without explaining why.
- Forgetting the context of pregnancy and extreme sports.
- Repeating the same idea twice, such as clotting risk in two different sentences.
- Talking about surgery risks — these were not credited.
📐 Model structure for a 4-mark response
- Point 1: Biological valves reduce the risk of blood clots.
- Point 2: So she is less likely to need lifelong anti-clotting drugs.
- Point 3: This is safer for pregnancy / a baby because drug risks are lower.
- Point 4: It is also better for extreme sports because there is less risk of serious bleeding after an injury.
Quick revision recap
💡 Remember
- Organ: different tissues working together.
- Valves: stop backflow of blood.
- Leak: less oxygenated blood reaches the body.
- Biological valves: lower clotting risk, but wear out.
- Mechanical valves: last longer, but need lifelong anti-clotting drugs.
🧠 Best exam habit
When a question asks you to “explain”, always connect the biology to the outcome. The examiner is looking for linked ideas, not just a list.
Topics
Biology · B2: Organisation
Question and mark scheme from the AQA GCSE Combined Science: Trilogy examination, Biology Paper 1 (Higher), 2022. QuestionVault is an independent revision resource; questions remain the copyright of the awarding body.