AQA GCSE Combined Science: Trilogy Biology Paper 1 (Higher), 2022: Question 6

9 marks · Standard Demand difficulty · Extended Answer

Answer questions about the heart, including why it is an organ, the effects of a leaking heart valve, and the advantages and disadvantages of using a biological valve instead of a mechanical valve.

Practise this question

Question

The question page is titled 'This question is about the heart' and contains three parts labelled 06.1, 06.2 and 06.3, worth 1, 4 and 4 marks respectively. Part 06.1 asks why the heart is described as an organ. Part 06.2 states that valves in the heart keep blood flowing in one direction and shows a simple grey outline diagram of a heart with one internal valve labelled by an arrow, then asks the student to explain the effects on a person if that valve developed a leak. Part 06.3 provides bullet-point information comparing biological valves and mechanical valves, including their sources, clotting risks, need for anti-clotting drugs and lifespan, then asks for the advantages and disadvantages for a young woman who enjoys extreme sports and wants to start a family of having a biological valve instead of a mechanical valve.
Question text

06 This question is about the heart.

06.1 Why is the heart described as an organ?

[1 mark]

06.2 Valves in the heart keep the blood flowing through the heart in one direction.

Figure 11 shows the heart with one of the valves labelled.

Figure 11

Explain the effects on a person if the valve labelled in Figure 11 developed a leak.

[4 marks]

06.3 Faulty heart valves can be replaced using biological or mechanical valves.

The faulty valve is replaced during an operation.

*26* Biological valves:

• are from animals or human donors

• allow blood to flow through them normally

• wear out and stiffen over time, so may need to be replaced.

Mechanical valves:

• are made from synthetic materials

• may cause blood clots on the surface of the valve

• require anti-clotting drugs to be taken for the rest of the patient’s life

• can last for a very long time in ideal conditions.

A young woman enjoys extreme sports and would like to start a family.

The woman needs a heart valve replacing.

Describe the advantages and disadvantages for this young woman of having a

biological heart valve instead of a mechanical heart valve.

[4 marks]

Mark scheme

Show the mark scheme The mark scheme is presented in tables for questions 06.1, 06.2 and 06.3 with columns for answers, extra information, marks and AO/specification references. For 06.1, one mark is awarded for stating that the heart is made of different tissues that perform specific functions. For 06.2, up to four marks are awarded for explaining that a leaking valve allows blood to flow back into the ventricle or heart, so less oxygenated blood is pumped to the body, cells have less oxygen for aerobic respiration, and the person becomes out of breath, has less energy transferred or feels tired. For 06.3, four marks are awarded for any four valid advantages and disadvantages of biological valves in this context, such as lower blood clot risk, no lifelong anti-clotting drugs, reduced risk in pregnancy or accidents, but possible rejection, need for repeat surgery, immunosuppressant drugs, or waiting for a suitable donor; a note says a maximum of three marks can be awarded if only advantages or only disadvantages are given.

Question 6

AO /

Question Answers Extra information Mark

Spec. Ref.

06.1 it is made up of (different) 1 AO1

tissues (that perform specific 4.2.1

functions)

AO /

Spec. Ref.

06.2 some blood would flow back into allow not all the blood would 1 AO2

the ventricle / heart leave the ventricle / heart 4.2.1

allow blood clot (may form in the 4.2.2.2

heart) 4.2.2.4

do not accept blood would flow 4.4.2.1

back into the right ventricle

(so) less oxygenated blood ignore references to glucose 1

would be pumped to the body

cells require oxygen for allow more anaerobic respiration 1

respiration

or

less aerobic respiration

(so) person would become out (so) lactic acid will build up 1

of breath

or

(so) less energy transferred allow the idea of lacking energy

do not accept less energy

produced / made / created

or

(so) person would be tired– OMBINED SCIENCE: TRILOGY – –

AO /

Spec. Ref.

06.3 max three marks if only AO3

advantages or disadvantages of

4.2.2.2

biological valve given

any four from: 4 4.2.2.3 25

4.2.2.4

(advantages of biological valve):

• reduced risk of blood clots

which could cause heart

attack or stroke

• reduced risk of blood clots

during pregnancy / birth

• reduced risk of bleeding

during pregnancy / birth

• do not need to take anti ignore do not need to take blood

(blood) clotting drugs thinners

allow do not need to take drugs

for life

• no risk to foetus / baby from

drugs

• reduced risk of serious bleeds

if in an accident

• do not need to carry (anti- allow problems related to losing

blood clotting) drugs when / obtaining drugs when travelling

travelling

• lower risk of rejection / do not credit reference to

immune reaction rejection twice

allow no risk of side effects from

drugs

(disadvantages of biological

valve):

• may be rejected do not credit reference to

rejection twice

• may have to go through ignore risks from surgery

surgery more than once unqualified

• may have to take

immunosuppressant drugs allow an animal might be killed

• have to wait for (suitable)

donor

Total Question 6 9

How to answer it

Heart valves: organ, effects of a leak, and valve replacement

What this question tests
Knowing that an organ is made of different tissues working together; understanding how heart valves prevent backflow; explaining what happens if a valve leaks; and comparing biological and mechanical valve replacements using advantages and disadvantages for a specific person.
Question 06 overview

Question focus

✅ Correct answers

  • 06.1: The heart is an organ because it is made of different tissues that work together for a specific function.
  • 06.2: A leak in the valve lets some blood flow backwards, so less oxygenated blood reaches the body.
  • 06.3: For this woman, biological valves avoid lifelong anti-clotting drugs, which is helpful if she wants children and does extreme sports.

🧠 Exam technique

  • Use the command word: “why”, “explain”, and “describe” need different depth.
  • For 4-mark explanations, chain cause → effect → consequence.
  • Compare biological and mechanical valves using the given context: pregnancy, sports, and medication.

❌ Common errors

  • Saying “an organ is a body part” without mentioning tissues.
  • Describing blood flowing into the wrong chamber instead of backflow from the valve leak.
  • For 06.3, giving only advantages or only disadvantages: that limits the mark.

Part 06.1 — Why is the heart described as an organ? [1 mark]

✅ Correct answer

The heart is made up of different tissues that perform specific functions.

This earns 1 mark because it states the key definition of an organ.

💡 Key knowledge

  • An organ is a group of different tissues.
  • The tissues work together to carry out a function.
  • For the heart, the function is pumping blood around the body.

🧠 Exam technique

For a 1-mark definition question, give the exact biology idea rather than a vague description. “Different tissues working together” is the safest wording.

Part 06.2 — Effects of a leaking valve [4 marks]

The valve should stop blood going backwards through the heart.

✅ Mark-point answer

  • Some blood would flow back into the ventricle / heart.
  • So less oxygenated blood would be pumped to the body.
  • Cells would have less oxygen for aerobic respiration.
  • The person would become tired / out of breath / have less energy.
You do not need all four points, but the explanation must link the leak to the final effect on the body.

💡 Key knowledge

  • Valves keep blood flowing in one direction.
  • If a valve leaks, it does not fully close.
  • That means not all blood leaves the ventricle or heart chamber.
  • Reduced oxygen supply means less aerobic respiration in cells.

🧠 How marks are awarded

Examiners credited each linked stage:

  • backflow happens
  • less oxygenated blood is pumped out
  • cells need oxygen for respiration
  • result: tiredness / breathlessness / less energy

❌ Common errors

  • “Blood would flow into the right ventricle” — this was not the accepted idea.
  • Talking only about glucose instead of oxygen.
  • Saying “less energy produced” is too vague unless linked to respiration.
  • Missing the final effect on the person, such as being tired or out of breath.

📐 Step-by-step chain for full marks

  1. The valve leaks.
  2. Some blood flows backwards instead of all moving forwards.
  3. Less oxygenated blood is pumped to the body.
  4. Body cells get less oxygen for aerobic respiration.
  5. The person becomes tired or short of breath.

Part 06.3 — Biological or mechanical valve for a young woman? [4 marks]

She enjoys extreme sports and wants to start a family.

✅ Strong answer points

Biological valves would be a good choice because:

  • They allow blood to flow normally and have a reduced risk of blood clots.
  • This is safer for pregnancy and birth because there is less risk of clotting problems or bleeding problems from anti-clotting drugs.
  • She would not need to take anti-clotting drugs for life, which is better for someone doing extreme sports because serious bleeding after an accident is less likely.
  • There is also less risk of problems for a foetus / baby from drugs.

💡 Key knowledge

Biological valves:

  • Come from animals or human donors.
  • Work normally with blood flow.
  • Wear out over time.
  • Usually do not need lifelong anti-clotting drugs.

Mechanical valves:

  • Are synthetic.
  • Can last a long time.
  • May cause blood clots.
  • Need anti-clotting drugs for life.

🧠 What top answers did

  • Gave both advantages and disadvantages of biological valves.
  • Linked the decision to the woman’s lifestyle and future pregnancy.
  • Compared against the mechanical valve idea, especially lifelong drugs and clotting risk.
For 4 marks, aim for 4 separate valid points. If you only write advantages or only disadvantages, the mark scheme says you can get at most 3.

❌ Common errors

  • Only saying “biological valves are better” without explaining why.
  • Forgetting the context of pregnancy and extreme sports.
  • Repeating the same idea twice, such as clotting risk in two different sentences.
  • Talking about surgery risks — these were not credited.

📐 Model structure for a 4-mark response

  1. Point 1: Biological valves reduce the risk of blood clots.
  2. Point 2: So she is less likely to need lifelong anti-clotting drugs.
  3. Point 3: This is safer for pregnancy / a baby because drug risks are lower.
  4. Point 4: It is also better for extreme sports because there is less risk of serious bleeding after an injury.

Quick revision recap

💡 Remember

  • Organ: different tissues working together.
  • Valves: stop backflow of blood.
  • Leak: less oxygenated blood reaches the body.
  • Biological valves: lower clotting risk, but wear out.
  • Mechanical valves: last longer, but need lifelong anti-clotting drugs.

🧠 Best exam habit

When a question asks you to “explain”, always connect the biology to the outcome. The examiner is looking for linked ideas, not just a list.

Topics

Biology · B2: Organisation

Question and mark scheme from the AQA GCSE Combined Science: Trilogy examination, Biology Paper 1 (Higher), 2022. QuestionVault is an independent revision resource; questions remain the copyright of the awarding body.