AQA GCSE Combined Science: Trilogy Biology Paper 1 (Foundation), 2024: Question 4

10 marks · Low Demand difficulty · Short Answer

Answer questions about gonorrhoea symptoms and data presentation, and explain risk factors, treatment and effects of plaque blockage in coronary arteries leading to heart muscle cell death.

Practise this question

Question

The question page is labelled Question 04 and states that it is about disease. Parts 04.1 to 04.4 focus on gonorrhoea: a multiple-choice question asks for a symptom of gonorrhoea from damaged immune system, pain when urinating, or reduced body temperature; a table titled Table 2 lists reported gonorrhoea cases per 100 000 population for five cities A to E with values 124, 118, 40, 130 and 40; further questions ask why the numbers may be inaccurate, which graph type best presents the data, and why the data are given per 100 000 rather than total cases. Parts 04.5 to 04.7 describe plaques in coronary arteries, include a simple labelled diagram of a narrowed artery with plaques on the inner wall, and ask which two factors increase plaque risk, which treatment should be used from placebo, stent or antibiotic, and to explain how a blockage can lead to death of heart muscle cells.
Question text

04 This question is about disease.

Gonorrhoea is a sexually transmitted disease.

04.1 Which is a symptom of gonorrhoea?

[1 mark]

Tick ( ) one box.

Damaged immune system

Pain when urinating

Reduced body temperature

Table 2 shows the number of reported cases of gonorrhoea for 5 cities.

Table 2

Number of reported cases

City of gonorrhoea per 100 000

of the population

A 124

B 118

C 40

D 130

E 13 40

04.2 The number of cases of gonorrhoea in each city might not be accurate.

Suggest one reason why.

[1 mark]

04.3 Which is the best way to present the data from Table 2?

[1 mark]

Tick ( ) one box.

Bar chart

Line graph

Scatter diagram

04.4 The data is given as per 100 000 of the population and not as the total number of

people with gonorrhoea.

Suggest why.

[1 mark]

Deposits can form in coronary arteries.

The deposits are called plaques.

Plaques cause damage to the arteries.

Figure 6 shows plaques in a coronary artery.

Figure 6

04.5 Which two factors increase the risk of plaques forming in the coronary artery?

[2 marks]

Tick ( ) two boxes.

High fat diet

Low blood glucose

Regular exercise

Smoking

Taking statins 15

04.6 Which treatment can be used for the plaques in Figure 6?

[1 mark]

Tick ( ) one box.

A placebo

A stent

An antibiotic

04.7 A heart attack can happen when plaques block a coronary artery.

During a heart attack muscle cells in the heart die.

Explain how the blockage can lead to the death of muscle cells in the heart.

[3 marks]

Mark scheme

Show the mark scheme The mark scheme is a table for Question 4 with separate rows for parts 04.1 to 04.7 and a total of 10 marks. It gives the accepted answers: pain when urinating for 04.1; for 04.2 any one from not all cases are reported, false positives or negatives, or population figures are estimates; bar chart for 04.3; for 04.4 comparison or different city population sizes; high fat diet and smoking for 04.5; a stent for 04.6; and for 04.7 a sequence of less or no blood flow, then less or no oxygen to heart muscle cells, then less or no respiration. The right-hand column includes AO/specification references corresponding to communicable disease, cardiovascular disease, gas exchange and respiration content.

Question 4

AO /

Question Answers Extra information Mark

Spec. Ref.

04.1 pain when urinating 1 AO1

4.3.1.3

AO /

Spec. Ref.

04.2 any one from: 1 AO3

4.3.1.3

• not all cases are reported / allow people may not know they 4.2.2.5

recorded have it

• (there may be) false positives allow idea of misdiagnosis

/ negatives

• references to population

numbers only being estimates

AO /

Spec. Ref.

04.3 bar chart 1 AO2

4.3.1.3

AO /

Spec. Ref.

04.4 to compare 1 AO3

4.3.1.3

or

different cities have different allow cities are different sizes

population sizes

AO /

Spec. Ref.

04.5 high fat diet 1 AO2

4.2.2.4

smoking 1 4.2.2.6

AO /

Spec. Ref.

04.6 a stent 1 AO2

4.2.2.4

AO /

Spec. Ref.

04.7 less / no blood (flow) 1 AO2

4.2.2.4

4.2.2.3

(so) less / no oxygen (to heart 1 4.4.2.1

muscle / cells)

(so) less / no respiration allow less energy available 1

ignore reference to lactic acid

Total Question 4 10

How to answer it

Gonorrhoea, Data and Coronary Arteries

AQA GCSE Combined Science: Trilogy
What this question tests
Spotting a correct symptom of a sexually transmitted infection, explaining why reported disease data may be unreliable, choosing the best graph for a set of category data, and recalling key facts about coronary artery disease, stents, and how blocked blood flow can kill heart muscle cells.
Overall focus: recall + data handling + simple biology explanations

Total marks: 10

Part (a) / 04.1 — Symptom of gonorrhoea [1 mark]

✅ Correct answer

Pain when urinating

This is the only option that matches the mark scheme.

💡 Key knowledge

  • Gonorrhoea is a sexually transmitted infection.
  • Common symptoms can include pain when urinating and unusual discharge.
  • Some people may have no obvious symptoms.

🧠 Exam technique

For a tick-box question, read all options carefully. One mark = one correct tick only.

Choose the symptom that is specific to the infection, not a general illness sign.

❌ Common errors

  • Damaged immune system is not a gonorrhoea symptom.
  • Reduced body temperature is not correct.
  • Students sometimes confuse symptoms of different diseases.

Part (b) / 04.2 — Why the number of cases might not be accurate [1 mark]

✅ Correct answer

Any one of these:

  • Not all cases are reported or recorded.
  • There may be false positives or false negatives.
  • Some people may not know they have it.
  • The figures may involve misdiagnosis.

💡 Key knowledge

  • Reported case numbers are not always the same as the real number of infected people.
  • Data in biology often depends on testing, diagnosis, and reporting.
  • Population figures can be estimates, so disease rates may also be approximate.

🧠 Exam technique

Because it says “Suggest one reason”, give one clear reason only.

A short explanation is enough if it clearly shows why the data may be unreliable.

❌ Common errors

  • Vague answers like “people lie” may not earn the mark.
  • Do not just say “it is hard to count” unless you explain why.
  • Top answers mentioned under-reporting or misdiagnosis.

Part (c) / 04.3 — Best way to present the data [1 mark]

✅ Correct answer

Bar chart

💡 Key knowledge

  • The data is for different cities, so it is categorical data.
  • Bar charts are best for comparing categories.
  • Line graphs are usually for continuous data over time.
  • Scatter graphs are for looking for correlation between two variables.

🧠 Exam technique

Ask: am I comparing groups, time, or two measurements?

Here, the cities are separate groups, so a bar chart is the clearest choice.

❌ Common errors

  • Line graph is wrong because the cities are not in a continuous sequence.
  • Scatter diagram is wrong because there is no pair of numerical variables to compare.

Part (d) / 04.4 — Why use cases per 100 000 people? [1 mark]

✅ Correct answer

To compare cities fairly because they may have different population sizes.

💡 Key knowledge

  • Using a rate per 100 000 standardises the data.
  • This lets you compare places with different population sizes properly.

🧠 Exam technique

The best answers say “to compare” and explain that the cities are different sizes.

That is enough for full marks in a 1-mark explain question.

❌ Common errors

  • Just saying “so it looks nicer” does not answer the science question.
  • Do not say it is because the number of cases is inaccurate — that is a different part.

Part (e) / 04.5 — Factors that increase plaque risk [2 marks]

✅ Correct answers

High fat diet

Smoking

Tick both of these for 2 marks.

💡 Key knowledge

  • A high fat diet increases cholesterol levels and plaque formation.
  • Smoking damages blood vessels and increases the risk of cardiovascular disease.
  • Regular exercise and statins reduce risk, so they are not correct here.

🧠 Exam technique

There are two marks, so two correct ticks are needed.

Read every option carefully. Some answers are risk factors, and some are treatments or protective factors.

❌ Common errors

  • Low blood glucose is not a plaque risk factor.
  • Regular exercise lowers risk, so it is not correct.
  • Taking statins is a treatment, not a cause.

Part (f) / 04.6 — Treatment for plaques [1 mark]

✅ Correct answer

A stent

💡 Key knowledge

  • A stent is a small tube inserted into an artery.
  • It helps keep the artery open so blood can flow through more easily.
  • Antibiotics do not treat plaque, because plaques are not caused by bacteria.

🧠 Exam technique

Look for the treatment that matches the cause of the problem.

Plaques in arteries are treated by opening the artery, not by using medicines for infection.

❌ Common errors

  • A placebo has no active effect.
  • An antibiotic treats bacterial infections, not blocked arteries.

Part (g) / 04.7 — How a blocked coronary artery can kill heart muscle cells [3 marks]

✅ Correct answer

  • The blockage means less or no blood flow to the heart muscle.
  • This means less or no oxygen reaches the heart muscle cells.
  • So there is less or no respiration, so the cells get less energy and die.

💡 Key knowledge

  • Heart muscle needs a constant oxygen supply.
  • Oxygen is needed for aerobic respiration.
  • Respiration releases energy for cell function and survival.

🧠 Exam technique

For 3 marks, write a chain of explanation:

blocked artery → less blood → less oxygen → less respiration → less energy → cells die

Each linked step can earn a mark.

❌ Common errors

  • Do not stop after saying “less oxygen”; you must explain the effect on respiration.
  • Do not write about lactic acid unless you know the question wants it — it was not needed here.
  • Top answers were short but linked clearly from blockage to cell death.

Quick recap: what examiners wanted

💡 High-scoring themes

  • Correct factual recall: symptom, risk factors, treatment.
  • Choosing the right graph for categorical data.
  • Explaining why rates per population are better for comparison.
  • Using a clear cause-and-effect chain in the heart question.

🧠 Mark-winning habits

  • Use the exact idea the mark scheme wants.
  • Keep answers precise and science-based.
  • For explanation questions, connect each step logically.

Topics

Biology · B2: Organisation · B3: Infection and Response · B4: Bioenergetics

Question and mark scheme from the AQA GCSE Combined Science: Trilogy examination, Biology Paper 1 (Foundation), 2024. QuestionVault is an independent revision resource; questions remain the copyright of the awarding body.